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Diphenhydramine (DPH, Benadryl): What You Need To Know

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Diphenhydramine is a antihistamine allergy drug that, when used in large amounts, provides sedative and deliriant effects. The experiences it provides are normally uncomfortable.

Diphenhydramine = DPH; Nytol; Sominex; Benadryl

Reddit discussion: https://www.reddit.com/r/TheDrugClassroom/comments/4elsdc/diphenhydramine_dph_benadryl/
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PsychonautWiki Page: https://psychonautwiki.org/wiki/Diphenhydramine

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diphenhydramine dph anticholinergics antihistamines deliriants hallucinogens benadryl sominex nytol

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50 Comments

    Popular Comments:

Crunchy Bee . 2019-02-18
Stuck my hand/arm through a door once because my hand kept going through the doorknob but I wanted out of the room. Started slowly with just my fingertips and it felt tingly like when a limb falls asleep.got almost all the way to my elbow before the tingle became so overwhelming it was painful. Thought I could maybe just run through the door real fast but somehow in this delirious yet very lucid state thought that might not be a good idea and might filter my soul or something and straight up kill me. So I sat back down and rode it out until I wasn't a ghost anymore. Must've "fell asleep" because I woke up able to touch things again. Always wondered why I didnt go through the floor. Maybe the door was never there and it was a waking dream. Just crazy how real the visual and tactile hallucinations were. Felt horrible too. Like having the flu minus vomiting. No fun and very dangerous. If I had gotten out of that room who knows what could've happened. My friend woke my parents up one night fiddling with their feet in their bed. When asked wtf he thought he was doing. He said he was working on this car. Lucky he didn't get shot. Stay away from this devils drug. Not cool or fun at all. Maybe if you knew what you were seeing wasn't "real" but nah. It blows my mind how such a dangerous drug is legal and otc and a lot safer drugs that have medicinal uses arent. It really makes me realize just how ignorant humans are. Anyone reading and thinking of trying. Don't. Stay away from this legal "high" please. I just don't want you to end up dead or in jail for murder because you thought your friends head was a cake. Someone in the UK cut his penis off. I know this is the kind of horror stories you hear about lsd but and never anything about something a kid could buy in a grocery store. You'd be a lot better off taking acid. Don't even begin to think they are the same but best to stay away from everything and focus on your life and what you need to do to get where you want to be instead of going inward to try and find the unknown. Just because you're not sure hell exist doesn't mean you want to go there just to find out because it may be permanent.
121 2 . Reply
Habib Habib . 2019-02-17
at 100mg per night, i cant tell the difference between not using or using it. Just a good buzz with a good sleep
121 2 . Reply
Christian Gallien . 2019-02-17
In most anecdotal reports, people tend to agree that 400mg is the average dose needed to really get the schizophrenic hallucinations.. (400mg was also the magic dose for myself when I tried). The best way for me to describe my experience with this drug is: It was VERY interesting, without any kind of euphoria whatsoever.. in fact dysphoric effects were present most often, just not quite intense enough to make the trips miserable.
121 2 . Reply
Redditdaily . 2019-02-14
That’s a fast onset
121 2 . Reply
Grigor Mironov . 2019-02-11
Hey Seth!
Thank you for providing so helpfull information on the effects of different substances :) it is illustrated so informativelly and it is presented in a way that makes it very interesting even for people who don't plan to try/use these drugs.
121 2 . Reply
Tim Bruse . 2019-02-11
I take 100 mg/night. 50mg 1-2 hours before bedtime and 50mg @ bedtime and have been doing so for a right at a decade. I have yet to experience any physical pathologies. I'm searching for others who do the same and have negative effects...
121 2 . Reply
Looser Kid . 2019-02-10
DO NOT TAKE DPH TO TRIP IT IS NOT A PLEASANT TIME TRUST ME
121 2 . Reply
John Gonzalez . 2019-02-10
So for years I have had a problem with benadryl most people will think I'm bull$*iting(I have nothing to gain from this)but after a few years of taking it everynight i had a habit of 50 pills a night. Yes literally took 36 in the first dose. Waited an hour for it to kick in and I started to feel sleepy and trippy,had to poop and smoke a ciggarette or two. And then after it started to work I would take another 14 to total if out to 50 pills of 25 mgs each. I would wake up the next morning (thank god!)and I would try to get up to get ready for work after sleeping for 6-8ish hours and I felt like i was drunk i would fall into the wall and stumble around and couldn't move properly. I tried to skateboard or ride a bike to work a few hours after I woke up and could barely hold it together. I would want to talk cause I felt I couldn't talk properly(I couldnt)and it took a good 6-8 more hours for me to come back to reality fully. In the end of it all it was a horrible experiance that I dont recommend to anyone! I was also using heroin or suboxone daily with it. I was pushing my body to the limit of wtf it could handle and I was lucky I didnt stop breathing all together during sleep. I tell people my experiance and they either laugh and say I'm lying or there mind are blown from hearing my struggle with it. I had to get drug tested every couple weeks to stay on my suboxone program and I would always test positive for methadone and occasionally pcp also. I didnt take methadone but the benadryl gave false positive results. Moral is DON'T BE STUPID LIKE ME AND USE/ABUSE DRUGS EVER IN YOUR LIFE!
121 2 . Reply
DXM LSA THC DPH DMT . 2019-02-10
425 mg. Absolute hell. Never again
121 2 . Reply
ReaperLegion . 2019-02-09
Guys as long as you don't do this over 2 times a year your all good my friend a couple of days ago took 775mg of diphenhydramine, yes he mixed to different brands one was allergy relief 550mg and 225mg of benadryl plus 2 Xanax and 1 beer... let's just say he turned into a different person
121 2 . Reply
revivedfears . 2019-02-08
Diphenhydramine is underrated as a sedative anxiolotic imo. 200mg is a good dose for this purpose, feels nice too.
121 2 . Reply
ScottFree 702 . 2019-02-07
I've taken over 20 I'm not sure how many exactly but I didn't hallucinate at all I did panic I thought I was going to die I couldn't even speak
121 2 . Reply
looneyhalls . 2019-02-04
I’m never doing this again and I highly recommend you don’t either about an hour after taking 500 mg the hallucinating started I saw spiders and webs all over the walls and black little whirlpool like swirls or sort of like an eyeball then I started talking to what I thought was my grandparents but the whole time no one was there but I saw a shadowy figure sitting as if there was, I also had this intense dreamy or light headed feeling the whole trip wasn’t enjoyable at all please don’t do this


Also the restless legs
Another thing is everyone is reporting seeing spider but mostly daddy long legs and that’s exactly what I saw and I thought I saw swarms of bugs in shadows
121 2 . Reply
TheFreePantheist . 2019-02-04
A+!! Please do one on kratom and kava!
121 2 . Reply
Kevin DiFranco . 2019-02-02
Let me advise from personal experience to NEVER EVER take more than 100mg for insomnia. My bad memory and impatience led me to taking 400+mg of the blue gels. You will have a trip that lasts 12 hours and you won't enjoy it or be able to control it. It is a fookin nightmare with the realistic visuals I've ever had. Also ended up getting arrested. I had lost my keys and thought they were in a friends car and I was singulary searching for them as I was looked out. Ended up looking in someone elses car who called the pigs. I had a warrant and other stuff. Was treated like crap by the police. Who kept asking me what I was on and wouldn't accept my answer- you wouldn't believe me if I told ya. Well I have a good lawyer and after a $750 retainer ended up paying an outstanding parking ticket and a $100 disorderly conduct. So kids don't try this horrible drug or any other H1 antagonist to get high.
121 2 . Reply
A.C. Jelly . 2019-02-02
I find even the recommended maximum dose of 100mg uncomfortable.

You're exhausted and all you want to do is sleep but your legs feel like they need to move and your skin gets too sensitive.
121 2 . Reply
wasupm87 . 2019-01-31
Idk you could get high off this shit thanks for the educational content
121 2 . Reply
Cuda FX . 2019-01-30
i'm surprised that low dosed used isnt even meitioned. 10-50mg already cause noticable effects, besides feeling cozily tired, that are quite pleassant, particularly in combination with other downers.
121 2 . Reply
ShalltearNB . 2019-01-29
Bruh someone tell me i took 8 advil pm thats 308 dihydrocodeine citrate and it has ibuprofen 1600 is that enough to overdose on or im i tripping
121 2 . Reply
kingmajin . 2019-01-29
this drug is one of the craziest i've done. i've done 1200mg, and maaaan....the shit you see and hear can be ridiculous. plus, i was doing some weird shit that i didn't even realize was weird shit. lol. plus, i could barely speak in any sort of proper manner
121 2 . Reply
Unknown Prodigy . 2019-01-28
I took 10 50mg and I just sat there watching my fish tanks. Keep in mind I also was high from weed and I took a couple shots of alcohol. I saw my fish cloning themselves and the walls started to look pink and blue and I saw circular patterns everywhere. I could not use the restroom I tried but I heard voices all over in my head saying you can’t piss repeatedly very fast. I went back into the living room I saw shadow people across the room when I tried to get closer and see who it was they would appear on the other side of the room. It was so hard to walk I was tripping on nothing. When I tried to use my phone that was sitting in the table it was impossible my hand would just phase through the table or it was like my phone was printed on the table. I walked around the living room all night and I was even putting my hands in my friends mouths who also took it and were sleeping. I was trying to investigate but I had no idea what I was touching because I was in the dark. When I woke up I had called my parents and texted them randomly jumbled letters. This is not something to be played with worst experience ever.
121 2 . Reply
Da Drumma . 2019-01-28
Regardless of anyone's personal experiences with this substance, the physical effects have been shown to be neurodegenerative in the long term. Just stick with booze and weed and don't fuck with stupid shit like this.
121 2 . Reply
cellogirl11RW . 2019-01-27
If Benadryl is supposed to be a sedative, why does 25mg make me bounce off the walls when I take it orally with nothing else?
121 2 . Reply
Amber Blyledge . 2019-01-27
I can't metabolize this. Like even getting cream on my hands makes my heart rate go up. I don't remember when I had the reaction, but my parents said that they had to finally throw a queen sized sheet on me and lay on it.

I also have issues with other downer types, such as hydrocodone (had a tooth pulled) and other sedative drugs, such as the ones they use in hospitals.
121 2 . Reply
Tyler Higham . 2019-01-26
Y’all crazy... a week or two back I took 12 and felt like only tired that’s it so I was like ok shit and the next night I took 40 and it fucked me lmao I felt like a noodle n my depth perception was destroyed so I was bumping into goddamn everything 😂 I’d rate it like 6/10 it was ok
121 2 . Reply
8-Brit Generation . 2019-01-25
If you wanna feel chill, Pregabalin does the job, even on the first dose you feel wrecked
121 2 . Reply
sonodi beach . 2019-01-25
Similar to mirtazipine. They market it as OTC sleep aid. Doesn't work very well for anything except a runny nose. 25-60 mg MAX.
121 2 . Reply
Corruptiion YT . 2019-01-25
Ive taken benadryl about 9 times now and every time the spiders come near me I'm afraid they will attack me so i close my eyes and occasionally I feel a pain on my body somewhere where the "spiders
121 2 . Reply
Muffin Man392 . 2019-01-25
tbh 50mg is kinda like xans and its pretty a ok imho
121 2 . Reply
coaltrain 12476 . 2019-01-24
I'm doing slightly over 500 mg later tonight. The pills are plastic coated I think should I just take the pills or break them? Thanks and please answer quickly only got a few hours
121 2 . Reply
TripleBug . 2019-01-23
“Unpleasant” man I was tripping 😂 I saw my walls melting and I took 7 Benadryl
121 2 . Reply
John Smith . 2019-01-23
I've tried delirient doses on multiple occasions, at 500 or 600 I saw aphids on the bed, and read the ceiling. At 800 I just had bad amnesia. Never saw anything really crazy at any point, and was dissapointed
121 2 . Reply
Squidlet Dos . 2019-01-22
I found that my perfect amount is 150mg, it relaxes me and makes everything feel smooth and buttery
121 2 . Reply
Dankest One . 2019-01-21
The delirium can be described as sleeping with your eyes open
121 2 . Reply
untangledunrestricted . 2019-01-20
I spent 72 hours in intensive care after being too stupid to know it wouldn't just put me to sleep. I took half a bottle of unisom in some complicated and naive attempt at suicide. Falling asleep with a rope around my neck basically. It was one of the most horrific events I have ever experienced. I was completely incapacitated once it kicked in. Couldn't stand up or communicate. Luckily my dog got scared and my mother downstairs came to check on me. I went to the hospital and was stuck in a bed with an IV and just had to wait it out. I was completely psychotic, but not aggressive. Thought my friends were with me in the room refused a catheter and couldn't stand to pee, couldn't bring food to my own mouth, couldn't really speak. Do not fuck with dph.
121 2 . Reply
Jimmi James . 2019-01-19
600mg would be raking 24 benadryl tablets. That would be stupid to do.
121 2 . Reply
Belony11zz . 2019-01-18
So you're saying it's better staying up all night then taking this I'm getting depressed after having bad sleeping patterns so I'm starting to look for natural Insomnia remedies and to fuck this drug off and also looking for headache remedies when there is no ibuprofen around.
121 2 . Reply
Belony11zz . 2019-01-18
This drug should be replaced with weed
121 2 . Reply
Ching Chong . 2019-01-18
This shit is scary. 400mg had me seeing spiders jumping off my wall and flying past ny face. You really think what your seeing is 100% real and normal so it wasn’t scary, but still fucking insane. Never again
121 2 . Reply
ANGELCHRISTINASTONE . 2019-01-18
I take it for sleep occasionally . 100-150 mgs.... I don’t understand ppl using it to get high because anything over 100-150 mgs gives u a extremely restless uncomfortable feeling
121 2 . Reply
Mew . 2019-01-14
4:26 Yeah there is only one product in the whole country that has DPH and they restrict that shit hard. Saying that I'm getting 1000mg in the mail in a few days. and just for shits I might get another box from a pharmacy, and maybe some DXM while I'm at it.
121 2 . Reply
GoldenBacon . 2019-01-13
How many mg does it take to start hallucinating
121 2 . Reply
Trisa Laird . 2019-01-09
Anyone else have extremely watery eyes after long term use?
121 2 . Reply
Less Fap - More Rap! & Jasper . 2019-01-09
I once took 750 MG of this lmao. - 😂 - Don't know how I survived, anybody ever do a dose That Big?
121 2 . Reply
free me . 2019-01-07
My chest gets tight I start trippin like I can’t breathe
121 2 . Reply
Jimmy johns . 2019-01-06
Lol my first time taking Benadryl when I closed my eyes I was watching a video and seeing cheeta patterns on my wall and shit I enjoyed it
121 2 . Reply
Dangelo Delgado . 2019-01-06
What is wrong with you fucks I just too 100 for insomnia but if you want it to fuck you up say 75mg and some melatonin your heart will be in your ass
121 2 . Reply
JulieTTe Aguirre . 2019-01-04
Gives terrible anxiety after used often in high amounts even when not under the influence.
121 2 . Reply
devon hopson . 2019-01-03
And yet they still sell it....
121 2 . Reply
Retr0Cat . 2019-01-02
I took 250mg felt like shit and thought it would never end I even had slight suicidal thoughts during it but I somehow ended up falling asleep thank god
121 2 . Reply
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