Diphenhydramine (DPH, Benadryl): What You Need To Know

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Diphenhydramine is a antihistamine allergy drug that, when used in large amounts, provides sedative and deliriant effects. The experiences it provides are normally uncomfortable.

Diphenhydramine = DPH; Nytol; Sominex; Benadryl

Reddit discussion: https://www.reddit.com/r/TheDrugClassroom/comments/4elsdc/diphenhydramine_dph_benadryl/

PsychonautWiki Page: https://psychonautwiki.org/wiki/Diphenhydramine

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diphenhydramine dph anticholinergics antihistamines deliriants hallucinogens benadryl sominex nytol

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    Popular Comments:

Less Fap - More Rap! & Jasper . 2018-12-13
Schizophrenia Simulator.™
121 2 . Reply
teachin bitches how to swim . 2018-12-12
Shits really nice at 200mg but it also really fucks up your body
121 2 . Reply
Kazoolhu . 2018-12-09
My friend took like eight hundred and pointed to a CD and told his dad to record him because he can play the skin flute LOL
121 2 . Reply
C_M . 2018-12-06
lmao all i see is if people had a bad trip they condemn it to hell as a devil drug that should be banned, but people that had better trips say it aint half bad.
121 2 . Reply
bexs 22 . 2018-12-06
I just took 50mg for anxiety and insomnia...now I might have hallucinations?
121 2 . Reply
National Nationalism . 2018-12-05
I've took 1500mg in a single day ones. It wasn't on purpose, I took like 600mg to get high, and in a delirious state I ended up taking the rest of the pills. I tripped so hard that I went out for groceries with my friends I haven't seen in years at 3 in the morning. My mom Obviously brought me to the hospital, where they Sedated me with Lorazapam and sent me off to Maryvale. A schizophrenic/Psychotic assessment facility. And now I have to take drug abuse counseling because when they tested my blood & piss, they found a whole lot of other shit that I never told them about.
121 2 . Reply
Nate Crawford . 2018-12-04
sooooooooooo glad i used this drug recreationally and regular enough to go through withdrawal. then go back to it long enough to fall into a psychotic state for a week and a half
also thought i wouldnt get addicted to it or dxm, or RC's. like most kids. but as we all know you're wrong to think that. if you aren't vulnerable to addiction you wouldnt be researching this drug.
121 2 . Reply
Ian Pearson . 2018-12-03
lack of sleep will impact you more than the side effects of these drugs.They arent supposed to be taken every night and in such high doses.
121 2 . Reply
Andres Terrazas . 2018-11-29
Cause ya cant sneeze if ya in a coma.
121 2 . Reply
Thaspacegoat Æ . 2018-11-20
Piece of shit “drug” fuck this garbage, you do it you’ll learn the hard way.
121 2 . Reply
Fabo Andolini . 2018-11-14
How long does it stay in your system? I failed a drug test because this shit can show up as methadone, I was taking a lot cuz I'm dumb like that, and I have a drug test tomorrow and it drives me crazy that I'm clean and still ha ing to worry about drug test cuz of fuckin zzzquil lol
121 2 . Reply
Rep . 2018-11-13
What if you mix mdma and benadryl to have a light trip?
121 2 . Reply
Olivia Lee . 2018-11-13
So I'm in the very VERY small minority in this but, the trips are not that bad for me. Well, as not bad delirium can reasonably be. I suspect it's because I OD'd on deliriants about two years ago, though even then it wasn't bad, once I got to the hospital and had my breathing regulated.

Again, I'm in the minority, if you are curious, have a trip sitter, take a LOWER dose, no more than 450 mg for your first time, and make sure your environment is comfortable, familiar and well lit.
121 2 . Reply
Kazaki (Crisel15) . 2018-11-12
As a person with allergic rhinitis, yep, it does cause you to have trippy dreams. You'll see some weird colors and shit, vivid imagery, realistic stuff, flying sealions with parrot wings, castles in the sky, rainbow water, etc. It's like an HDR mode on my regular dreams/nightmares. My dreams are already weird but antihistamine makes shit weirder, either for the best or the worst.

It also makes you lucid dream easier than with normal sleep (which is useful if you feel crap and don't wanna get out of bed). However, some nightmares include intense af amplification of my emotional traumas, waaaaayy more brutal than my average nightmares, which really sucks.

Mom likes to call that effect "in the twilight zone" XD
121 2 . Reply
Catherine Benton . 2018-11-11
I hae never taking 50 mg at a time. i cant imagine take 500 mg
121 2 . Reply
SoloDolo . 2018-11-09
I took around 900mg and saw these weird orb spiders. Then i could here my mom knocking and talking on the other side of my door, but everytime id open the door nobody was there. Kept happening over and over again,it was so clear/vivid that i was convinced someone was actually on the other side each time
121 2 . Reply
Kamil Skuba . 2018-11-09
im on 2 mg clonazepam 900 mg of diph and weed rn. im good
121 2 . Reply
Troy Miller . 2018-11-07
Sorry to be random but I demand that you be my husband! lmfao
121 2 . Reply
DawiM U . 2018-11-06
Thank you for this informative video.

Why we should not use it with other active ingredients?
121 2 . Reply
tinycomedian . 2018-11-04
What if someone used this with other pain meds such as hydrocodone or gabapentine?
121 2 . Reply
Sean The Baptist . 2018-10-21
Just remember this if you plan on using Diphenhydramine as a hallucinogen, the hallucinations are negative and very scary 99% of the time. You will not enjoy it.
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Mike Soots . 2018-10-17
The 27th of October 2018 is my first year awoke from a 5 year coma from benadryl I am left with retrograde amnesia suffered a massive stroke a t.b.i cardiac failure and respiratory failure went status eplipticus on top of that when I awoke I had to learn how too walk talk eat and use the bathroom all over it has caused a neurological condition as well as heart problems that will eventually kill me, my suggestion to you all is your dumb if you really think this is the way to trip, what my doctor told me is pharmaceutical companies are making new ingredients// inactive mixed with the tripping ingredient that no longer makes you trip but instead throws you into status eplipticus cardiac failure and die.. they started doing this one month before I decided to try and trip stick with shrooms trust me on this it's the same ingredient in robitussin they added as well.
121 2 . Reply
Buzzcut . 2018-10-15
Fuck this drug. I walk walking like a cowboy because my legs felt so fucking heavy. Then tried running away from my shadow super slowly and bowlegged...
121 2 . Reply
Mullet Head . 2018-10-12
Yep, my kidneys get shocked and I pee a lot. And yes, I get horny as faa and want to fap. This is 250mg of this stuff, I'll stop for few days cause my tolerance , then set sails again....Ambien is a total knock you out pill. I cut one in half one time to take and woke up sideways, arms sprawled, legs dangling off my bed with the lights on and fully clothed not remembering how I got like that.
121 2 . Reply
This guy . 2018-10-08
What kind of idiot gets high of of Benadryl??
121 2 . Reply
knowledgeiskey0110 . 2018-10-05
one time i took 17 ambien tens.. thats the closes to a diliriant i have ever done. i blacked out and was talking to the sky with my hands to the sky, presumably god? my parents were abnormally nice to me, even made me breakfast, then they told me how i was acting smh.
121 2 . Reply
stop asking me to change my name! . 2018-10-03
Is this also called Gravol ? Is it safe to take 50mg daily before bedtime?
121 2 . Reply
Vayln Ninetails . 2018-10-03
I rocked a 925mg dose and every time I have used it I have enjoyed it. DPH is a very picky drug. Having used it about 5ish times I always had a good mind set and took showers during the come up. I have heard of the Spiders at first it looked like smoke was coming out the wall and waves going across my walls. I read about it and wanted to see it about 50mins too an hour in (Keep a stop watch so you can keep mental note that the drug is in you and for how long helps me at least) I seen the spiders it kinda creeped me out but the few times I forgot about the drug and seen them close it kinda spooked me. Just stay calm and ride the motions of the trip. SIDE NOTE: I have been taking DPH for allergys years before I knew I could trip on it. This could have played into why I can handle it well even at insane levels. its a 6/10 trip all in all, but the risk of a bad time is very high unless you are a very lucky person so it seems.
121 2 . Reply
Shark_bait_da_cherry . 2018-10-02
I took one to get rid of a migraine and when I woke up I was sweating and I was pale I’m scared to take that shit again
121 2 . Reply
Quinlan Maverick . 2018-09-29
Who the fuck would take more than 50mg of Benadryl.
121 2 . Reply
Bizaron . 2018-09-27
Well, I found out that some people who took this regularly in recreational doses (yep, these little fiends exist) developed brain tumours. It seems that as an antihistamine, this stuff decreases your protection mechanisms against tumours (it doesn't cause them) for a while. And popping like 50 benadrylz erryday would most likely leave you very vulnerable to tumours for a very long time, essentially giving them time to form.

However, occasional recreational use should probably not posses a high risk for this shit or maybe you can take that with same prohistamines (Idk if that exists lol) or something to counter this effect.
121 2 . Reply
Michael K . 2018-09-26
It’s not cool, and it’s not kids’ stuff.
121 2 . Reply
S. Salvatore . 2018-09-24
I get seizures from this stuff. Guys be always carefull with meds! Wow I did not even know this was usable to get High. I only knew its againts vomiting and I have to stay the hell away from it. But I get seizures from al lot of drugs
121 2 . Reply
wock . 2018-09-23
I randomly told this girl to take 600mg because I had nothing else better going on in my life and literally she couldn't understand shit going on around her and she kept talking to random people and texting on her phone backwards. It was funny as hell at first but after like 2hours I was annoyed because my friend and I had to literally keep full tabs on this bitch.
121 2 . Reply
Kathy Davis . 2018-09-22
Dumass don't u know this stuff can kill u??? U could go into a coma brain dead then lets see how fun this shit is!!!
121 2 . Reply
matthew drury . 2018-09-17
I literally get all those negative effects but fuck it
121 2 . Reply
Dual Morality . 2018-09-16
I use this as a sleep aid [insomnia]; Approximately 150mg per night
121 2 . Reply
Austin Yipeo . 2018-09-15
To anybody taking it, you’ll feel like shit. I’ve never played music because anticolinergics block serotonin and dopamine.
121 2 . Reply
Bizaron . 2018-09-08
Ok so despite my datura fascination, I found no way how to use it "safely," meaning the bag of seeds will most likely stay sealed forever. I have also educated myself in anticholinergics and antihistamines as I got my hands on some diphenhydramine (here in Czech Republic, we have mephenhydramine, which I suspect will have very similar effects as it is an antihistamine and anticholinergic as well and is called "Kinedryl.")

I am still ressearching potential physical dangers of DPH and I found this disconcerning statement on psychonaut wiki:

"Diphenhydramine has been shown to block sodium channels and inhibit the reuptake of serotonin. It also blocks voltage-gated potassium channels (VGKCs), meaning it has the potential to cause or lead to torsades de points, a potentially dangerous cardiac condition that can lead to sudden cardiac death."

If I am not mistaken, cocaine does a very similar thing and thus can result in sudden cardiac death (that's why I am not touching that stuff ever again). However, DPH sounds like it won't cause sudden cardiac death by its own effects but rather first lead to "torsades de points" which can lead to cardiac arrest.

Therefore, I would like to ask whether it is neccessary to reach a certain dose of this substance to put myself at such risk or whether it can occur at any or if I need to have a history or at least a family history of cardiac problems. Also, so far I am reading about the anticholinergic syndrome (which causes the delirium), I still did not find a clear statement whether this syndrome is able to simply stop the functions some of the organs it affects (mostly lungs and heart).

Also, anyone tried tantum verde? That stuff is apparently a deliriant as well and pretty undiscovered, it's also not an anticholinergic so it might not be so uncomfortable or outright dangerous.
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bridget . 2018-09-07
most i’ve ever taken was around 800mg. the whole night i walked around with my friends tripping balls. near the end of the night i was sitting talking to all of my friends at what i thought was one of their houses, and they started to disappear and i realized i had been talking to a tree in a neighborhood that i had never been in before. i was only 3 hours into the trip.
121 2 . Reply
Puzzy Monsta . 2018-09-07
Is there a way to extract only the diphenhydramine from these pills?
121 2 . Reply
House Phone . 2018-09-03
Why are people trying to trip off of this. I just use it to sleep lol. 38 mg is good enough.
121 2 . Reply
Jupiter . 2018-09-02
I get very strong close eye hallucinations
121 2 . Reply
Isabella Maillet . 2018-08-31
I was just looking up the drug benadryl because I ended up taking it after I had a really bad allergic reaction to the amoxicillin I was taking, and I found this video. Ended up being prescribed prednisone along with a steroid ointment because it wasn't working on it's own. At least I know what happens if I take too much.
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Joe Lauder . 2018-08-30
i took 40 25mg benedryl. i was fucked
121 2 . Reply
Ashton Lindgren . 2018-08-28
Bruh i fuckein ate 600mg of dis benadryl and it was exactly like that time my gramma gave me special juice
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Yolo Swag . 2018-08-27
took 250mg 40 min later didnt hit me took 250mg and 40 min later didnt notice anything took 250 more got very happy and went to the bathroom strangers kept calling for me to get out and i freaked out ran upstairs and hid under a blanket and was paranoid that they would get me i thought giant spiders were trying to find me and the walls looked like gel and my phone was hard to use then i passed out total of 750mgs
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Shadow X . 2018-08-25
😮 I probably should have watched this BEFORE swallowing 26 of them.

Oh, well. This won’t be even close to the stupidest thing I’ve ever done. Besides......delirium is HIGHLY underrated.
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Mr. Buttonz . 2018-08-16
Diphenhydramine is also addictive. If taken for a long enough period of time, large dosage daily use for its euphoric properties, there are wothdrawl symptoms including night terrors, body shocks, nauseousness, and overactive runny nose and other hightened allergy symptoms,
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GAY GAY . 2018-08-15
guys honestly Benadryl is better than benzos if you are in a chill state of mind and don't get paranoid that is
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